A multifaceted approach to expanding healthspan

Cambrian is developing a pipeline of new therapies that selectively target the nine hallmarks of aging, designed to repair the damage that accumulates in our bodies as we age.

The Hallmarks of Aging

By building new medicines that target the mechanisms underlying disease, we can treat damage at the molecular level long before symptoms manifest – a transformative approach to medicine that Cambrian is leading. [1]

Molecular alterations

Our cells consist of DNA, RNA, proteins, fats, and other small molecules. Some of these molecules are long-lived and become damaged over time, impeding their function; others are over-produced as we age, building up and forming aggregates as the ability of our cells to recycle these molecules declines.

Cellular dysfunction

Our organs and tissues consist of trillions of cells, each of which has a life of its own. Cells must remain healthy and functional to contribute to the overarching function of a tissue. However, as we age, whole networks of cellular processes can stop functioning leading to a decline in organ function and health.

Tissue degeneration

The ultimate job of our cells and molecules is to uphold the function and integrity of our tissues, allowing for a balanced healthy state called homeostasis. Three categories of age-related changes can negatively impact entire tissues from achieving this balance.

[1] Adapted from López-Otín, C., et. al., Cell. 2013 Jun 6; 153(6): 1194–1217.

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