Cambrian Bio is a clinical-stage drug development company focused on building therapeutics to treat and ultimately prevent some of today’s most debilitating chronic diseases, including platforms targeting critical metabolic pathways that decline with age such as AMPK, mitochondrial activation, and MTOR.

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Cambrian is advancing programs from early clinical development through value creating inflection points. As the organization enters its next phase of growth, the Clinical Operations function is expanding to support multiple concurrent clinical studies with increasing operational complexity.

Cambrian is seeking a Senior Clinical Trial Manager (SCTM) to support the planning, execution, and day-to-day management of clinical trials. This role will be responsible for the oversight of all vendors including but not limited to the CRO as well as study timelines, and budget tracking.

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The Senior Clinical Trial Manager will report to the Senior Director of Clinical Operations and will work closely with internal clinical leadership, external CROs, consultants, and functional partners. This role requires comfort operating in an early-stage biotech environment and a strong sense of ownership across studies.

Clinical Trial Execution & Oversight

• Manage the day-to-day execution of assigned clinical studies, from startup through closeout.
• Serve as the primary point of contact for CROs and external vendors, overseeing performance against scope, timelines, and budget.
• Actively manage study timelines, milestones, and deliverables, identify risks, and propose mitigation strategies.
• Support CRO selection processes and contribute to vendor contracting and scope development as needed.

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Budget Management

• Track and manage clinical trial budgets in close partnership with Clinical Operations leadership.
• Review CRO invoices and ensure alignment with contracts, work orders, and study progress.
• Monitor vendor resourcing and utilization to ensure cost-effective execution.

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Cross-Functional Coordination & Communication

• Coordinate with internal stakeholders (Clinical Operations, Regulatory, Finance, external consultants) to ensure alignment on study plans and execution.
• Provide clear, structured updates on study status, enrollment, timelines, risks, and budget to Clinical Operations leadership.
• Prepare materials and summaries to support internal reviews and decision-making.

Required

• Bachelor’s degree and approximately 5+ years of experience in clinical operations or clinical trial management within biotech or pharmaceutical environments.
• Prior experience in small or early-stage biotech companies.
• Highly execution-oriented, with strong attention to detail and follow-through.
• Proven experience managing CROs and external vendors for clinical studies.
• Experience supporting Phase 1-3 clinical trials.
• Strong understanding of clinical trial timelines, budgets, and operational workflows.
• Experience supporting study start-up activities.

Cambrian offers competitive compensation packages that are made up of base salary, bonus, and equity:

• Salary: $130,000-$155,000 offered to NYC employees, commensurate with relevant experience; salary range may vary depending on state of residence
• Bonus: Performance-based bonus opportunity
• Equity: Employee stock options vesting over four years with a one-year cliff

In addition to being part of a collaborative and mission-driven team, Cambrian offers a comprehensive benefits package, including:

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• 16 company holidays and an unlimited vacation policy
• Comprehensive medical, dental, and vision insurance with fully employer-paid coverage options for employees
• 401(k) with pre-tax and Roth contribution options
• Employee Assistance Program providing free, confidential support through Optum’s Life and Work Well
• Flexible Spending Accounts (FSA) and Health Savings Account (HSA)
• Adoption assistance
• Short- and long-term disability coverage
• Basic life and AD&D insurance, with optional voluntary life insurance