Cambrian is seeking a Director, R&D Project Management to support the TORnado platform as its projects advance through late preclinical, IND-enabling, and early clinical development. The Director, R&D Project Management will be responsible for execution of complex development activities, coordinating cross-functional workstreams, tracking progress against project plans, and supporting the generation of high-quality data to enable regulatory submission and clinical progression. The position will report to Cambrian’s VP, R&D Project Management, and be a member of the TORnado platform team. This role blends strong R&D project management fundamentals with scientific engagement, requiring close collaboration with scientific leadership, cross-functional partners, and external collaborators as development activities evolve in scope and complexity.

R&D Project Management

• Responsible for the execution of late preclinical, IND-enabling, and early clinical development activities for TOR-101.

• Develop, maintain, and actively manage project management tools including detailed project plans and execution trackers aligned with platform objectives and milestones.

• Identify and proactively manage dependencies, risks, and execution gaps across functions (e.g., partnering with CMC experts to ensure timely production of adequate material to support critical path studies).

• Monitor progress across multiple concurrent workstreams, ensuring alignment to timelines and critical path milestones.

• Support preparation and coordination of materials for project reviews, development discussions, and regulatory activities.

• Provide clear, structured updates on progress, risks, and dependencies to support decision-making.

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IND-Enabling and Early Clinical Support

• Plan and coordinate IND-Enabling studies, including pharmacology and toxicology studies, working with internal teams and external partners to align study designs with R&D goals and secure timely delivery of critical resources.

• Partner with scientific leadership and external experts such as consultants and CROs to translate the development strategy into executable plans and study designs.

• Identify risks, dependencies, and gaps within assigned workstreams and proactively surface them with proposed mitigation strategies.

• Support preparation of documentation and summaries for scientific, development, and regulatory-facing discussions (including Pre-IND Meeting materials and IND submission).

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Cross-Functional and External Coordination

• Coordinate day-to-day interactions with internal teams (R&D, CMC, operations) and external partners, including CROs and academic collaborators.

• Collaborate with internal functions (Business Operations and Legal) to ensure timely review, approval, and execution of contractual agreements with external R&D partners.

• Monitor scopes of work, timelines, and deliverables with external vendors to support consistent execution.

• Ensure accurate documentation, version control, and traceability across development activities.

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Scientific Engagement

• Develop and maintain a working understanding of TOR-101, including mechanism of action, development rationale, and key scientific questions.

• Engage actively with scientific data and technical discussions for informed project management and issue identification.

• Apply scientific context to planning, sequencing, and risk assessment to improve execution quality.

• Support intellectual property strategy and filings.

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Required

· PhD required in a relevant scientific discipline (e.g., biology, pharmacology, chemistry, or related field).

· 8-10 years of experience in R&D project management within biotech or pharmaceutical development.

· Proven experience managing late preclinical and IND-enabling programs.

· Demonstrated ability to manage complex, cross-functional R&D activities with attention to detail and proactive follow-through to meet project needs.

· Strong organizational and communication skills, with the ability to synthesize scientific and technical information.

· Track record in building and maintaining internal and external relationships, such as with CROs and academic research partners.

· Experience in planning and managing toxicology studies.

· Experience supporting the preparation and submission of an IND, including coordination of cross-functional inputs and timelines.

· Comfortable operating in fast-paced, resource-constrained environments with evolving priorities.

Preferred

· Experience supporting early clinical stage programs.

· Familiarity with programs supported by public or non-dilutive funding (e.g., government grants), including related reporting or compliance considerations.

· Experience in small or emerging biotech organizations.

Cambrian offers competitive compensation packages that are made up of base salary, bonus, and equity:

· Salary: $145,000 - $175,000 offered to NYC employees, commensurate with relevant experience; salary range may vary depending on state of residence

· Bonus: Performance-based bonus opportunity

· Equity: Employee stock options vesting over four years with a one-year cliff

In addition to being part of a collaborative and mission-driven team, Cambrian offers a comprehensive benefits package, including:

· 16 company holidays and an unlimited vacation policy

· Comprehensive medical, dental, and vision insurance with fully employer-paid coverage options for employees

· 401(k) with pre-tax and Roth contribution options

· Employee Assistance Program providing free, confidential support through Optum’s Life and Work Well

· Flexible Spending Accounts (FSA) and Health Savings Account (HSA)

· Adoption assistance

· Short- and long-term disability coverage

· Basic life and AD&D insurance, with optional voluntary life insurance