The Neuroscience of Aging: Assessments, Treatments and Modeling in Aging and Neurological Disease - Chapter 46: Modeling Nutrition and Brain Aging in Rodents


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Aging is the greatest risk factor for most neurodegenerative diseases including dementia. Nutrition has a profound impact on aging, and certain dietary interventions may have the potential to reduce the risk of neurodegenerative disease. Caloric restriction (CR) is one of the most robust nutritional interventions to improve brain health during aging; however, the relative contributions to the effects of CR of reduced energy intake, one or several macronutrients (protein, carbohydrate, or fat) or periods of fasting are unknown. The geometric framework (GF) has been used to determine the role of macronutrient intake on health and life span in mice with results indicating that ad-libitum low-protein, high-carbohydrate diets positively influence health and life span in model organisms. The GF may also be used to investigate the influence of macronutrient intake on brain health in aging rodents.