Nature Reviews Drug Discovery (May 2021 Cover Story): Strategies for delivering therapeutics across the blood–brain barrier (Georg C. Terstappen; EVP, Drug Discovery)

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A review of recent developments and challenges related to selected blood–brain barrier-crossing strategies — with a focus on non- invasive approaches such as receptor-mediated transcytosis and the use of neurotropic viruses, nanoparticles and exosomes — and analysis of their potential in the treatment of CNS disorders.

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